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Recruitment procedures
Under the direction of Janine Pembroke (Nurse Co-ordinator for
the MRC BRIGHT Study) the research programme has now successfully
recruited two hypertensive family resources using the MRC General Practice
Framework. Over 1700 affected sibling pairs have been recruited for the primary purpose of performing a genome screen for hypertension genes. 800 hypertensive trios (affected proband and parents) have been recruited for fine mapping and candidate gene studies. We are currently recruiting normotensive controls, which are age, sex and geographically matched to the hypertensive probands from our sbling pair resource. This new resource will augment our current collection allowing powerful association and replicative studies to be performed.
In order
to attain consistency in phenotyping, genetic counselling and
recruitment procedures the Nurse Co-ordinator developed Standard
Operating Procedures (SOPs) accompanied by regular training
updates for all the study nurses.
Figure 1
will now guide you through the standardised recruitment process
for the sib pair study. Should you wish to view some of the
documentation used for the study please click on the relevant
links.
Figure 1
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Recruitment
co-ordination
j.c.pembroke@qmul.ac.uk
Regional nurse contact details
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Contact
MRC GP Surgeries
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Return
of Questionnaire
MRC BRIGHT nurse telephone/letter contact
Verification of interest and willingness to participate
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Telephone
Screening by MRC BRIGHT Nurse
Confirm eligibility of each family member
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Obtain
pre-diagnosis BP records for each member
Ensure GP details correspond to affected individuals responses
for eligibility and that each member is well enough to
donate a blood sample
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Screening
visit arranged for each member
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Visit
Provide written invitation to participate to each member
Obtain Informed Consent
Record personal history details in questionnaire booklet
Record phenotypic measurements
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Completion
of each family
Provide subjects GP with phenotypic measurements
File all records using unique study number
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| © MRC
BRIGHT Study 2003 All Rights Reserved. |
| The
material on this site is protected by copyright
and all related intellectual property rights. By
accessing and downloading the material on this
site, you agree not to make a substantial copy
of any of the papers (unless for private study)
without first seeking prior permission of the webmaster,
Richard Dobson (r.j.dobson@qmul.ac.uk). You may
use the material contained on this site for such
private study only if you credit the work to the
BRIGHT study. You acknowledge that all other use of
the work, and particularly your use of the work
for commercial gain, is forbidden. |
